Penile cancer is the growth of malignant cells (cancer cells) in tissues of the penis. Penile cancer usually occurs uncircumcised men and it suggests that there is a correlation between circumcision and penile cancer. Circumcision decreases the concentration in smegma and reduces the chances of infections developing in the foreskin, like potentially oncogenic human papilloma virus. Human Papilloma Virus DNA is seen in approximately 50% of cases diagnosed with penile cancer. Usually penile cancer is common among men ages between 40 and 70.
The survival of the case is depend on the clinical stages, degree, and histological grades of the tumor. Usually patient with stage 1 penile cancer can be cured.
Penile cancer signs and symptoms
- Lump or swelling on penis
- Abnormal discharges
Penile cancer risk factors
- Men age above 40
- Poor Personal Hygiene
- Phimosis (a condition in which the foreskin of the penis cannot be pulled back over the glans).
- Having Multiple Sexual Partners
Penile cancer morphology
Squamous cells carcinoma of penis usually starts on the glans and inner surface layer of the prepuce, forming papillary and flat masses. The papillary ulcers (lesions) may form a cauliflower like fungating masses. Most cases a flat like lesions appear as some regions of epithelial thickening is accompanied by graying and fissuring of the mucosal surface. In some cases, due to ulceration, sever bleeding and hemorrhagic are observed.
Penile cancer metastasis
Penile cancer cells metastasize deeply along with penile shaft and spread to inguinal lymph nodes, and then iliac lymph nodes, and disseminate to distant organs in later stages.