What You Really Need to Know about Cancer

Wednesday, October 15, 2014

Types and classification of malignant connective tissue tumors

Malignant connective tissue tumors or mesenchyme are called sarcomas. Sarcoma accounts 1% of all malignancies in adults. However, it’s the fourth most common type of malignancy in children after hematopoietic
neoplasm and, neural tumors, and Wilms tumor.

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Malignant connective tissue tumors: Liposarcoma

Liposarcoma
Liposarcoma is malignant neoplasm of adipocytes or fat cells. It usually occurs in adults, with a peak incident in the fifth to sixth decades and are one of the common soft tissue malignancy in age group.It normally seems as a slowly growing, non-ulcerated, painless and submucosal mass. However, some lesions grow very fast and become ulcerated at early stage. The five different types of liposarcomas are:
  • Well-differentiated liposarcoma
  • Dedifferentiated
  • Myxoid
  • Round cell
  • Pleomorphic
The functional and structural distribution of the liposarcoma depends on its histologic type. Differentiated liposarcoma occurs predominantly in the retperitonium and Well-differentiated liposarcoma occurs in deep soft tissues of both the limbs and also in the retroperitoneum.

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Malignant connective tissue tumors: Fibrosarcoma

Fibrosarcoma
Fibrosarcoma is a malignant neoplasm of mesenchymal cells composed of malignant fibroblasts. Mostly it occurs in adults, usually the sites of origin includes the deep tissue of thigh, knee, and retroperitoneal area. They normally have a slow growth and they have usually been present for several years by the time they are diagnosed.  There are two types of fibrosarcomas. (1) Primary and (2) secondary fibrosarcoma. Primary fibrosarcoma is a fibroblastic malignancy which produces variable amount of collagen and Secondary fibrosarcoma of bone originates from a preexisting lesion. Secondary fibrosarcoma is more aggressive and have poor prognosis than primary fibrosarcoma.

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Malignant connective tissue tumors: Rhabdomyosarcoma

Rhabdomyosarcoma
Rhabdomyosarcoma is malignant mesenchymal neoplasm that exhibits skeletal muscle differentiation or cancer of the muscles that are attached to the bones. It can occur at different parts of the body including head, neck, arms, leg, and urogenital tract.  In contrast to soft tissue sarcoma, rhabdomyosarcoma is predominantly neoplasm of infancy, childhood, and adolescence, with peak incident at the first decade of life.

There are mainly three types of Rhabdomyosarcoma

Embryonal: The most common type of rhabdomyosarcoma and usually occur in head and neck.
Alveolar: Usually occur in arms and legs
Anaplastic: very rare type of rhabdomyosarcoma that occur in children.

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Malignant connective tissue tumors: Leiomyosarcoma

Leiomyosarcoma
Leiomyosarcoma,is a malignant smooth muscle tumor,it often arises from soft tissues, usually occurs in the uterus and gastrointestinal tract, however it arises in any area of the body. Leiomyosarcoma is comparatively rare form of neoplasm of soft tissue and accounts for between 5–10% of soft tissue sarcomas. Usually leiomyosarcoma occurs in the uterus, stomach and intestines, the walls of all blood vessels, and the skin. Often Leiomyosarcomas are more common in adults than adults.

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Malignant connective tissue tumors: Synovial Sarcoma

Synovial Sarcoma
Synovial sarcoma derive from mesenchymal cells in the joint cavities and accounts for 10% of all soft tissue sarcomas. A characteristics and apparently unique chromosomal translocation is present in the vast majority of synovial sarcomas. Synovial Sarcoma is common in large joints of the legs and arms but previously it has been documented that Synovial Sarcoma occurs in most human tissues including brain, prostate and heart. Synovial sarcoma usually occur in adolescents and young adults.

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Malignant connective tissue tumors: Osteosarcoma

Osteosarcoma is the malignant tumor of osteoblasts, which is the most common primary tumor of bone excluding multiple myeloma. It usually occurs at the second decade of life and also common among people of age above 60 years. It commonly occurs in the ends of the long bones of the body, which include bones of the arms and legs.  The majority arises around the knee and upper arm.

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Malignant connective tissue tumors: Chondrosarcoma

Chondrosarcoma
Chondrosarcoma is a malignant neoplasm populated by mesenchymal cells that produce a cartilaginous matrix. Males are more affected than female. Unlike osteosarcoma, chondrosarcoma occurs in elderly people with peak incident at the six decade of life. Usually, chondrosarcoma arises from central portion of skeleton, common sites include, pelvis and shoulder areas. There are two types of chindrosarcomas. Primary chondrosarcoma, is uncommon and arises centrally in the bone, and often found in children. Secondary chondrosarcoma originates from benign cartilage defects such as osteochondroma

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Malignant connective tissue tumors: Angiosarcoma

Angiosarcoma
Angiosarcoma is a malignant tumor of blood vessels endothelium. It is characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels endothelium. It occurs in both male and female and usually occur in elderly people or sixth decade of life. Itcan be found in anywhere in the body but often found in the skin, soft tissues, breast, and liver. 

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  1 comment:

  1. Till know I was only known with Liposarcoma a type of cancer that most often develops from fat cells. It is most commonly found in your legs or thighs, but it can also be found in your abdomen, back, arms, chest, and neck. Liposarcomas cancer most often occur in people between the ages of 50 to 70 years old. The exact cause of liposarcoma is not known, but it may be caused by damaged genes. Liposarcomas more commonly occur in an area of your body that has been injured. You may be at a higher risk if have received radiation treatment in the past. Find out more about effective treatments for liposarcoma cancer & various options available from the experts and get liposarcoma prognosis. Thanks.

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