Tumor suppressor genes are normal genes that slow down cell division, repair and DNA mistakes, and tell when to die ( it is also called programmed cell death or apoptosis )when these genes don’t work properly concerned cells can lead cancer.
Types of tumor suppressor genes
Name of the gene Related cancer
BRCA 1, BRCA 2 Breast and Ovaian cancer
BRC-Abl Chronic myelogenous leukemia
BCI2 B Cell lymphoma
HER2 Breast cancer and Ovarian cancer
Ews Ewing tumor
C-myc Burkitt’s lymphoma
P53 Brain tumor, Skin Cancer, Lung cancer, head and neck cancer
MCHI , msH2 Colorectal cancer
APC Colorectal Cancer
The Rb gene is well know tumor suppressor gene located at 13 q14.11 and is detect at the germ line in one half of chromosome the child inherits in familial neuroblastoma. Afterward it was found that a part from retinoblastoma homogenous loss of this gene was fiarely common in osteosarcoma, pineal, supraseller, paraseller intracranial retinoblastoma. of the from retinoblastoma
TP 53 Gene
Is the most commonly muted gene in human cancer. It is also known as guardian of the gene. TPm53 protein is released from MDM2 and its half life is increased. This gene is deleted or mutated in 70% to 80% of cases of colorectal cancer and frequently in breast cancer, small cell carcinoma of the lung, hepatocellular carcinoma and numerous other tumors. Mutation of TP 53 is the most common genetic change in human cancer.
This is located at 11p13. Deletion of this gene is associated with Wilm’s tumor.
BRCA and BRCA 2 Gene
The breast cancer genes are susceptibility genes, which are also incriminated in some ovarian cancers, are tumor suppressors that are thought to be involved in check point functions of the cell cycle in response to DNA damage.