Mesothelioma is a rare neoplasm arising from mesothelial cells lining the pleural cavity. This malignancy is associated very strongly with asbestos exposures. Approximately 50% of the patients have a history of exposure to asbestos.
Pleural mesothelioma characteristically encases and compresses the lung, extending into fissures and interlober septa. The areas of the necrosis with the tumor give rise to large cystic spaces containing mucinous fluid.
1. Epithelia, in which cuboid cells line tubular and microcystic spaces, into which small papillary buds project.
2. Predominantly fibrous mesothelioma is made up of fine spindle cells arranged in whorls and straps
3. Combination of two
These are highly malignant tumors that spread around the pleural cavity and pericardium, encasing the lung and mediastinal structures.
Pleural mesothelioma tend to spread locally within the chest cavity, invading and compressing major structures. Metastasis can occur to the lung parenchyma, and mediastinal lymph nodes, as well as to extrathoracic sites such as liver, bones, periosteum and adrenals.
Mesothelioma Signs and Symptoms
The average age of patient with mesothelioma is 60 years. Patients are first seen with pleural mass, chest pain, and nonspecific symptoms such as weight loss and malaise.